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If GHK-Cu penetrates poorly through intact skin, the observed clinical effects could be occurring primarily at the epidermal level rather than reaching dermal fibroblasts where collagen synthesis occurs

1994 Mar-Apr;30(2):310-9

By microdosing, the body adjusts gradually, making the process more tolerable and sustainable

doi: 10.1016/j.neulet.2008.12.053 96 HeYLinYSongJSongMNieXSunHet al

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The high dose also improved oral glucose tolerance, suppressed hyperinsulinemia, and cut microvesicular liver steatosis by 73%