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Tirzepatide has a slightly higher molecular weight, which theoretically makes it even less likely to transfer into milk, but both appear similarly safe based on available studies
However, the human skin acts as a powerful barrier, making it extremely difficult to deliver large peptide molecules like semaglutide or tirzepatide in therapeutic doses through intact skin
If it remains cloudy or foamy, discard it
It fundamentally changes what this class of drugs can achieve
These observations are usually temporary and can be addressed with proper research protocols
What This Means for Industry Participants While this week in no way settled the compounded GLP-1 debate, it did, however, show how quickly the conversation can accelerate when FDA signaling and branded manufacturer enforcement converge in a high-demand category
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