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Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice Nat Microbiol 2021;6(5):563-573 doi:10.1038/s41564-021-00880-5 (Animal and cell study
Butyrate indirectly increases cAMP, which activates IGN in intestinal cells, while propionate, a substrate for IGN, activates the GPR43 receptor, triggering gluconeogenesis, which converts to glucose
Then as needed
Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase
And for others, it can help them taper off a GLP-1 while reducing their risk of rebound weight gain especially if they pair it with other lifestyle changes like regular physical activity and a nutritious diet
Peptide therapy uses carefully selected peptides to reinforce or restore these natural signals
