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Future innovations may expand choices, but understanding current options and their differences remains essential for making informed decisions about your treatment today

Nature 392 (6679 Suppl

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When to seek medical advice: Experiencing unusual weakness or fatigue beyond initial adjustment Difficulty performing usual daily activities Concerns about nutritional adequacy Rapid weight loss exceeding 1 kg per week consistently Your GP or prescribing clinician can provide personalised guidance, potentially including referral to a dietitian or exercise specialist

Additionally, rapid weight loss associated with GLP-1 therapy triggers ketosis in some patients, and ketones can produce a fruity or acetone-like smell on the breath

Semaglutide and tirzepatide suppress appetite and slow gastric emptying, often reducing daily calorie intake by 20 to 35%