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For the full titration schedule and when to increase your dose, see our [semaglutide dosing schedule guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)

Key Takeaway: If the dosage is high enough, the pill is just as effective as the injection for weight loss

Immunoblot assays Tissue samples were crushed on dry ice to obtain homogenous aliquots and then lysed in RIPA buffer (Thermo Scientific #89900) containing Halt protease & phosphatase inhibitor (Thermo Scientific #1861280)

Clin Pharmacol 13:5360

Report any sleep difficulties to your trial team, who can assess whether the medication may be contributing and advise on any adjustments

Detailed AMSTAR 2 and GRADE assessments are provided in supplementary data 2 and 3