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Companies that begin integrating GLP-1 thinking now, at the formulation, regulatory, and positioning levels, will be best positioned to lead as the convergence of pharma and functional continues to accelerate.

In analyses excluding individuals with no BMI information and using multiple imputation for BMI missing values, respective HRs were 0.89 (95% CI 0.26, 3.14) and 1.29 (95% CI 0.42, 3.92) (Table 2)

The clinical evidence for CIRS relies heavily on specific, objective biomarkers rather than just symptom reporting

Additional ASCO GI 2026 analyses focused on adenoma recurrence, a validated surrogate endpoint in colorectal cancer prevention research

By the 1960s, it was recognized that incretin hormones were responsible for 50-70% of the insulin response to oral glucose

Risks: Potential for skin irritation, allergies, or contact dermatitis