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These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]

These results highlight semaglutides early action on decreasing major cardiovascular events, with significant benefits already evident by the first 6 months, and for some, even earlier, even before any major weight loss and before most patients would have been titrated to their full target dose of 2.4 mg, said lead author Dr Jorge Plutzky, Director of Preventive Cardiology, Cardiovascular Medicine at Brigham and Womens Hospital, Boston, MA, USA and a member of SELECT Steering Committee

GLP-1RAs engage pro-survival pathways in the mouse heart, improving outcomes following myocardial infarction and enhancing survival (107)

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What we do have is two strong signals pointing the other way