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This selectivity matters because MC1R activation in skin tissue triggers anti-inflammatory signalling without the pigmentation effects associated with broader melanocortin agonism
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Zhao Q, Yang R, Wang J, Hu D-D, Li F
Supports antioxidant activity
In a db/db mouse model of type 2 diabetes, dapagliflozin treatment for 12 weeks inhibited the expression of TGF- , MCP-1, osteopontin and ICAM-1, and thereby inhibited diabetes-induced inflammation in the kidneys (154)
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