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GIP, specifically, reduces appetite by affecting the brain

Contact your healthcare provider or seek prompt medical evaluation if you experience any of the following symptoms: Persistent, Severe Vomiting: If you cannot keep fluids or your daily medications down for more than 24 hours, you run a serious risk of dehydration

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Evidence From Clinical Trials on Cardiovascular Outcomes Phase 2 data (NEJM 2023) showed systolic blood pressure reductions of approximately 46 mmHg and a modest heart rate increase, but no cardiovascular outcome trial exists for retatrutide and definitive conclusions about cardiovascular benefit or risk cannot yet be made