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Nave CD4 + T cells live in lymphoid organs and it is unlikely that inflammatory macrophages regulate the fate decisions of such T cells prior to their differentiation into memory/effector cells

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Bourgeois B, et al

Preclinical rodent studies support effects on angiogenesis, endothelial function, and nitric-oxide-related signaling, though these effects are reproducible in animals but not yet validated in humans

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