To address them, the field is rapidly developing new frameworks, as seen in recent perspective papers we published, discussing "clock-to-clock" analysis and using diseases as a testbed for longevity interventions
There is so much more to explore
Tumor Suppressors: In some cancer types, p53 suppresses GLS activity
[2] Researchers report that VIP and its analogs have been proposed as promising alternative candidates to existing [research] for acute and chronic inflammatory and autoimmune diseases. Compromised barrier function leads to increased antigenic material in the space between cells, which interacts with immune cells to trigger an inflammatory response
406,407 Chronic iron deposits in the liver can lead to liver fibrosis, cirrhosis, and eventually HCC
Frontiers in Aging Neuroscience, 14 , 888292