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4.3 Risk-related factors: exposure characteristics, co-occurring symptoms, and baseline susceptibility Within the current evidence base, the occurrence and phenotype of GLP-1RA-associated changes in eating experience can be interpreted as being shaped by exposure characteristics, co-occurring symptoms, and individual susceptibility
IP-1: intervening peptide 1
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However, the role of FXR in improving metabolic dysfunction is contentious, as intestine-specific FXR agonism improves the metabolic profiles of mice 274,275 and increases the expression of TGR5 276 , which mediates bile acid-induced GLP-1 secretion from EECs 277
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Semaglutide used once weekly is bound to albumin in the blood allowing for a longer effect or once weekly dosing
