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1 This retrospective analysis, conducted in Istanbul, evaluated 106 adults with newly diagnosed T2D who were prescribed either semaglutide (1.0 mg) or dulaglutide (1.5 mg) alongside a hypocaloric diet of 1200 to 1400 calories per day

At the 24-week mark, the mean increases in heart rate were: 1 mg dose: +4.1 bpm 4 mg dose: +6.1 bpm 8 mg dose: +7.9 bpm 12 mg dose: +7.8 bpm These increases were observed to be maximal around 24 weeks and then showed a slight attenuation, though they remained elevated above baseline for the entire 48-week study period

Human studies reported only minor shifts, with Lactobacillus being one notable increase

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Notably, mice lacking GLP-1R exhibit reduced brain uptake of fluorescently labeled Liraglutide 66