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Semaglutide (single GLP-1 receptor agonist): In the STEP 1 trial, participants on semaglutide 2.4 mg achieved approximately 14.9% body weight reduction at 68 weeks
Yu H, Zhang D, Zhang L, Li Q, Song C, Shang X, et al
Most stomach issues resolve on their own
Nature Genetics 50, 668681.CrossRefGoogle ScholarPubMed Zheng, HY, Reiner, DJ, Hayes, MR and Rinaman, L (2019) Chronic suppression of glucagon-like peptide-1 receptor (GLP1R) mRNA translation in the rat bed nucleus of the stria terminalis reduces anxiety-like behavior and stress-induced hypophagia, but prolongs stress-induced elevation of plasma corticosterone