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7 In line with the overall theme of patient-centered care, the ADAs recommendations for intensification beyond metformin monotherapy include careful consideration of patient- and drug-related factors when determining the best regimen for a given patient
The ROMK protein is a member of the inwardly rectifying K + channel proteins that are also designated K ir with ROMK being K ir 1.1 (three isoforms of ROMK result from alternative splicing: K ir 1.1a, K ir 1.1b, and K ir 1.1c)
Differences in the composition of the amino acid sequence between the porcine and human peptide could also have affected their biological activity, in particular the degree to which they activated the release of insulin
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