Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T
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History of Cancer : These peptides are not recommended to be administered to patients with active cancer or recent tumor growth because these medications stimulate growth hormone release and may aggravate tumor growth, especially those cancers involving breast and prostate
Thus, copper supplementation may be a good measure to manage depression
Authors contributions Both authors contributed equally as far as the conception of the article is concerned
GH therapy, when effective, can improve mood and cognitive function as IGF-1 normalizes