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Rare, but Serious Risks: Pancreatitis (inflammation of the pancreas) Gallbladder issues Kidney complications in those with existing kidney disease Also, people with a personal or family history of medullary thyroid cancer or MEN-2 should avoid these medications

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The liver is especially relevant because it produces and uses large amounts of SAM, manages homocysteine through both remethylation and transsulfuration, synthesizes glutathione and carries out methylation- dependent reactions

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DOI: 10.1056/NEJMoa2301972 The Lancet Urva S

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In clinical trials, it lowered HbA1c by 1.5 to 2.5 percentage points depending on dose and baseline levels

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