Hansen et al., in their commentary on Humphrey and Lawrences paper [87], emphasized that several studies have demonstrated improvements in quality of life associated with GLP-1 RA-induced weight loss, along with health-related benefits such as enhanced cardiovascular outcomes that outweigh the impact of facial aging
When combined with RNA complex, glutathione, and collagen, skin regeneration acceleratesresulting in brighter tone, firmer texture, and long-lasting radiance
These observations suggest that during pharmacological GLP-1R agonism, the net effect of -arrestin recruitment is to reduce prolonged insulin release
Pract Diabetes 38:3134 Das A et al (2015) New treatments for diabetic retinopathy
doi: 10.1210/jc.2005-1536 81 CorpasEHarmanSMPieyroMARobersonRBlackmanMR
The oral vs injection comparison for tirzepatide breaks down these trade-offs in more detail