Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation
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In contrast, CRC cells are associated with gut microbiota imbalances, such as an increase in harmful bacteria and a decrease in beneficial microbes, which may result in disrupted fatty acid metabolism [78]
In another study, intraperitoneal injection with GLP-1 analogue (Val)GLP-1 enhances neuronal stem cells and neurogenesis in the dentate gyrus of brain in wild type mice, so it may have potentially beneficial effects in the CNS (167)
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During this time, their bodies may struggle to break down and use fats and sugars, particularly while fasting or during illnesses like gastroenteritis