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Patients taking multiple medications should discuss potential interactions, though GLP-1 receptor agonists have minimal hepatic metabolism interactions

Storage requires refrigeration at 2 to 8 degrees Celsius, consistent with standard peptide storage guidelines

Background GLP-1R agonists protect the blood-brain barrier (BBB): These drugs help maintain the integrity of the BBB by preventing tight junction degradation, which can reduce the risk of neuroinflammation and cognitive decline

Medications that work normally without adjustment The following medications have been studied in combination with semaglutide and require no dose or timing changes: Metformin

A 2024 review in the Journal of Clinical Investigation found no increased risk of pancreatitis or pancreatic cancer with long-term GLP-1 use