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Karpiski TM, Oarowski M, Seremak-Mrozikiewicz A, Wolski H

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Whilst vitamin B12 toxicity is exceptionally rare, very high levels from supplements or injections have been associated with skin reactions such as acne-like eruptions

For example, adalimumab as a TNF inhibitor blocks the bind of TNF and its receptors to reduce cytokines (like MMP-1 and MMP-3)-driven inflammatory processes, which suppresses the destruction of cartilage and bone ( Figure 1 On the other hand, several cytokines, including IL-4, IL-10, IL-13, and TGF-, exert anti-inflammatory effects in RA

Research Stage: Preclinical only