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Oxidative stress is a major contributor to the high mortality rates associated with SARS-CoV-2 infections (Poljsak et al., 2013

(2023) Mitochondrial quality control via mitochondrial unfolded protein response (mtUPR) in ageing and neurodegenerative diseases

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Specifically, the combination of MCT4 inhibition with ferroptosis inducers not only depletes lactate accumulation but also enhances CD8+ T cell infiltration and ferroptosis-driven ICD, thereby synergistically improving checkpoint blockade efficacy (111)