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AGEs activate inflammatory and oxidative pathways within the joint tissue 15

Women clear GLP-1 agonists more slowly than men

Phase 3 ATTAIN-1 trial data showed that the highest dose (36 mg) produced an average 12% weight loss, approaching Wegovy's 15% benchmark

In a phase 3 randomized, controlled clinical trial, participants treated with tirzepatide achieved an average weight loss of around 20% of their body weight over 72 weeks

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PACAP contributes to insulin secretion after gastric glucose gavage in mice