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Colonic mRNA expression analysis in Glp1r / mice at baseline reveal significant reductions in trefoil factor ( Tff-1 and -2), transforming growth factor ( Tgf-b1 and Tgf-3 ), epidermal growth factor receptor ( Egfr ), keratinocyte growth factor ( Fgf7 ), hepatocyte growth factor ( Hgf ) (epithelial protection and repair), Il6, Il1b (innate immune response), Il12b (inflammation) (Yusta et al., 2015)
In recent years, IDH inhibitors targeting IDH mutants, including ivosidenib and enasidenib (Table 1), have been approved by the Food and Drug Administration to be used in patients with IDH1 or IDH2 mutant recurrent or refractory AML, respectively (Kim, 2017
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Evidence from metabolism studies, case reports and larger systematic retrospective case reviews but no prospective controlled trials demonstrate that following single acute paracetamol overdose , children may be relatively protected from acute liver injury and hepatotoxicity when compared to adults [15, 46, 51,52,53, 58]
