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doi:10.1016/j.pharmthera.2021.107916

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Several areas warrant medical oversight

CagriSema is given as a once-weekly injection under the skin

For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

Together, they create a synergistic effect that addresses every aspect of joint health from immediate pain relief and enhanced absorption to deep tissue repair and long-term joint regeneration