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schon vor knapp 20 Jahren per radioaktiv markierten Fettsuren nachweisen, dass die Carnitingabe die Oxidation dieser Fettsuren um 30 % steigert (1)
Compared with VDAC blockade, USP30 inhibition benefits from enzymatic tractability and measurable pharmacodynamic readouts, although its efficacy is still likely to depend on residual integrity of PINK1/Parkin-associated quality control pathways in the target cells
Both acute and chronic use of addictive substancessuch as cocaine, alcohol, and heroin-can result in drug-induced depression 5,9,12,14
10.1080/02791072.2002.10399983 72 MalhotraA