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44 : 577585 Taglialatela G, Navarra D, Olivi A, Ramacci MT, Werrbach-Perez K, Perez-Polo JR et al

Presented for research literature review only Vos O et al

11,12 This model proposes that the RBD-PD subtype follows a body-first trajectory, in which -synuclein pathology originates in the peripheral or enteric nervous system (ENS) and subsequently ascends via the vagus nerve to the brainstem, particularly the locus coeruleus/subcoeruleus complex, which is considered one of the core pathological nuclei involved in RBD

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Hypoxic conditions skew macrophage polarization toward an M2-like phenotype, characterized by anti-inflammatory, tissue-remodeling, and pro-tumorigenic functions

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