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70 This evolutionary dynamic has been demonstrated in NSCLC and melanoma treated with PD-1 blockade and explains why tumors with high mutational burden may still acquire rapid resistance to immunotherapy
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Hematocrit, reticulocyte count, vitamin B12, folate and iron levels should be obtained prior to treatment
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doi:10.1016/j.crohns.2012.08.011
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M., Dudziec, E., Peter, S., Bertz, S., Hartmann, A., Bryant, H
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Nutrient treatment should follow laboratory findings and the patients biochemical pattern
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Antioxidants may act as suitable sperm preservation agents given their beneficial effect on preserving sperm quality [60]
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