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At higher supplement doses (5002000 mcg), only about 12% is absorbed passively, but this is still effective for treating a deficiency
Numbness or tingling in hands and feet Peripheral nerve changes are a more serious sign of prolonged deficiency
Ods.od.nih.gov
Severe or persistent abdominal pain, especially if accompanied by vomiting or systemic symptoms, should be evaluated promptly
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doi:10.1210/endo-91-6-1393
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