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Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension
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But other side effects include making you feel fuller and delaying the emptying of your stomach so youre not hungry for a longer time
At this concentration, a 300mcg dose equals 12 units (0.12ml) on an insulin syringe
Mixing up oral and injectable Oral semaglutide doses (3-25 mg daily) are much larger than injectable doses (0.25-2.4 mg weekly) because absorption from the gut is very low (about 1%)
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