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Glucagon-like peptide-1 (GLP-1) receptor agonists semaglutide and tirzepatide, which have been approved by the US Food and Drug Administration for the treatment of obesity and diabetes, may also reduce symptoms in patients with obstructive sleep apnea (OSA)
GLP-1 signaling also antagonizes voltage-dependent K + (Kv) channels via cAMP/PKA-dependent pathway in beta cells, which prevents beta-cell repolarization by reducing Kv currents
We now know that patients frequently discontinue GLP-1 therapy within months, negating long-term benefits, and also struggle to meet the requirements of lifestyle changes that are prescribed alongside the medication
Some side effects are known and documented
As we age or encounter environmental stressors, our natural glutathione levels may decline, compromising our respiratory function
Bliddal, H
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