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Experimental vessel tone, endothelial phosphorylation markers, NO-related readouts, and tissue vascularization can be influenced by model design, species, tissue preparation, assay timing, and injury or stress conditions

DSIP has small, mostly decades-old studies with fewer than 50 participants each

Reported in small human studies: Headache, dizziness, and transient blood pressure changes were noted in some early studies

Manufacturers may deliberately add banned substances or inadvertently cross-contaminate supplements due to inadequate quality control at stages of production and packaging

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Precision and accuracy are different things, and a chart delivers only the former