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In MASLD, reduced SIRT1 activity leads to hyperacetylation and stabilization of PLIN2 and PLIN3, effectively locking lipid droplets and impairing lipophagic clearance, exacerbating triglyceride accumulation
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In addition, gut microbiota dysbiosis is found to be closely related to neurodegenerative diseases (Shen et al., 2017
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