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These therapies display higher efficiency compared to classical senolytic drugs (BCL-2 or tyrosine kinase inhibitors) but for some of them, such as NA + /K + ATPase inhibitors, clinical development could be complex in the light of strong cardiotoxicity associated with this class of molecules

Indeed, selective activation of PGC-1 within the hepatocytes protects the liver from lipids overload and progression to fibrosis, due to its ability to induce mitochondrial oxidative phosphorylation, fatty acids -oxidation and citrate cycle, while decreasing oxidative stress and promoting triglycerides excretion in the bloodstream 15

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Specialized assessments : If needed, we evaluate inflammation markers or metabolic health

Boiling may lead to greater losses, while steaming or lightly cooking vegetables may help preserve more of their beneficial nutrients and antioxidants

These purified HBs demonstrated robust self-renewal capacity, expanding in a small-molecule-defined medium (ACDFSV) for over 20 passages without losing their proliferative capacity or characteristic morphology