Selvaraju V, Baskaran S, Agarwal A, Henkel R
TME-mediated cancer resistance and combating strategies The TME in cancer resistance The TME constitutes a critical layer of therapeutic resistance in which immune and stromal cells, extracellular matrix remodeling, and vascularmetabolic constraints jointly restrict drug and immune efficacy (Fig
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if they dont settle, the studied response is to slow the pace, not to push through
For RAD51 foci, 4 h following irradiation, cells were fixed and immunostained with anti-RAD51 antibody (1:2000