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Finally, although our meta-analysis showed that GLP-1 receptor agonists increased the risk of overall thyroid disorder, due to the decrease in sample size, it did not show statistically significant results for specific thyroid disorder

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Most of the studies did not report the duration for which the patients received treatment with SGLT2i or GLP-1RA until add-on was initiated, which would have provided insights into the extent of heterogeneity in the timing of therapy titration

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