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This not only indicates that oral semaglutide has similar efficacy in the treatment of obesity compared to the injectable form but also that its oral route of administration may help overcome psychological barriers to injection therapy for some patients, thus improving compliance and acceptance
As explained, there is a rationale for the combined use of basal insulin and GLP-1RAs
Consuming 5-6 small portions helps prevent overwhelming the slowed digestive system
However, the same study also found lower/more attenuated post-prandial responses of GLP-1 and GIP [106], consistent with findings from a subsequent study that found worsening OSA was associated with reduced GLP-1 levels [107]
1u) and acute HFD intake, to comparable extents to that produced by intraperitoneal injection (Fig
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