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Some people report experiencing more energy or improvements in their self-esteem, and sexual health
Lin WH, Huang CJ, Liu MW, Chang HM, Chen YJ, Tai TY, Chuang LM
Chem Biol Drug Des 99(2):247263
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We've seen interesting data using infusions of tevogrumab (anti-myostatin) +/- garetosmab (anti-activin A) in combo with #semaglutide (data will also be presented at #ADA2025 ) Bimagrumab: an ActRII blocker with a unique mechanism Inhibits myostatin and activins Increases lean muscle mass while decreasing fat mass Phase 2 Data (JAMA Netw Open, 2021) In adults with T2D and obesity: Fat mass: 20.5% Lean mass: 3.6% Body weight: 6.5% Waist: 9 cm HbA1c: 0.76% BELIEVE Study (NCT05616013) A Phase 2b RCT evaluating: Bimagrumab (currently infusion) vs placebo Alone or with #semaglutide In adults with BMI 30 or 27 with complications Results due at #ADA2025 later this month NCT06643728 A Phase 2 RCT evaluating: Bimagrumab (SUBCUTANEOUSLY) vs placebo Alone or with #tirzepatide In adults with BMI 30 or 27 with complications over 70w Expected completion Jan 2027 If BELIEVE confirms bimagrumabs effects, we may soon have the first anti-obesity drug that builds muscle
Examples include: Dilantin (phenytoin) Norvir (ritonavir) and other medicines that contain ritonavir, such as Kaletra Phenobarbital Sustiva (efavirenz) and other medicines that contain efavirenz Tegretol (carbamazepine) Drugs that are metabolized by an enzyme called CYP2D6 Bupropion inhibits an enzyme called CYP2D6, which could lead to increased levels in the body of certain medications (examples are listed below), referred to as CYP2D6 substrates
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