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These effects are supported by vitro experiments examining telomerase expression over a longer period of time

doi: 10.1186/s13075-017-1357-2 187 LiMLiuXSunXWangZGuoWHuFet al

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The intracellular glutamate concentration is nearly 10-fold higher than the Km value, but intracellular cysteine concentrations approximate the apparent Km value [10] , indicating that cysteine may be a limiting substrate for GCL