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Pre-existing risk factors : Individuals with established osteoporosis, previous fragility fractures, advanced age (particularly postmenopausal women), low baseline BMI, or those taking medications that affect bone metabolism (such as corticosteroids) may be more susceptible to bone density changes during weight loss

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Selective inhibition in astrocytes alone was sufficient to prevent non-cell-autonomous neuronal loss and prolong survival, as a mechanism of neurodegeneration driven by reactive astrocytes (Smith et al., 2020)

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Many may be marketed using language that may mislead consumers and violate FDA and FTC advertising rules