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Committees evaluate whether potential benefits justify animal use

Eighty-six percent (86%) of ZEPBOUND-treated patients had a maximum tolerated dosage of 15 mg weekly based on their final dose during the double-blind treatment period

These effects generally indicate either starting doses too high or individual sensitivity

Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]

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This can lead to increased skin elasticity and firmness over time