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Billingsley, A

In 2024, the FDA also approved Zepbound to treat moderate-to-severe obstructive sleep apnea in adults with obesity

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Clinical Uses: Nausea & vomiting (postoperative, drug-induced, migraine-associated) Diabetic gastroparesis Gastroesophageal reflux disease (GERD) Facilitation of small-bowel intubation Adverse Effects: Extrapyramidal symptoms (EPS) such as dystonia, tremors Drowsiness, restlessness Long-term use Tardive dyskinesia Contraindicated in Parkinsons disease & bowel obstruction Clinical Tip: Use short-term (12 weeks) when possible

11 Investor expectations amplify market value: The $697 billion surge in market capitalization reflects not only the revenue potential of GLP-1 products but also heightened investor confidence in their long-term profitability

The arc from villain to engine is the single most interesting scientific story in metabolic disease in the last decade, and it is the reason the triple agonist pathway exists as a category