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Tang J, Su T, Huang K, Dinh PU, Wang Z, Vandergriff A, Hensley MT, Cores J, Allen T, Li T, et al

On the other hand, oral replacement may improve adherence for patients who prefer oral medication to injections

3hyperreflexia, e.g., coiling flexor spasm and clonus in response to light touch or stretch

29 There is also a lack of data on the long-term benefit of oral therapy when patients do not take daily doses

Importantly, clinical outcomes have been mixed: the large LOVIT randomized trial in adults with sepsis (Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit, Lamontagne and colleagues, New England Journal of Medicine, 2022, n=863) found that high-dose IV vitamin C was associated with a higher risk of death or persistent organ dysfunction than placebo

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