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GIP receptor activation may contribute to improved metabolic function, while GLP-1 receptor agonism primarily mediates appetite suppression through central nervous system pathways affecting satiety centers in the hypothalamus

In animals, obesity does not impair GIP or GLP-1 secretion from isolated perfused preparations of small intestine, and weight loss does not influence GLP-1 secretion [57]

Patients of childbearing potential should also receive counseling on contraception and planned pregnancy, since the review notes limited pregnancy data and recommends stopping GLP-1RAs at least two months before planned conception

Lilly intends to seek regulatory approval for the indication

GP, GL, VC, and VL contributed to the clinical follow-up of patients

Months 612 People often continue losing weight at a steady but slower pace