Thus, dietary supplement B 12 supplementation at 500 to 1000 g per day allows pernicious anemia and certain other defects in B 12 absorption to be treated with daily oral megadoses of B 12 without any correction of the underlying absorption defects
While the low starting dose of 0.25 mg is specifically designed to mitigate these adverse effects, many patients will still experience some mild discomfort as their system adapts
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Holm S, Mackiewicz Z, Holm AK, et al