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The effects of MPC inhibition have been shown to be associated with increased oxidation of the BCKA via activation of the dephosphorylation of the BCKD by the phosphatase, PPM1K

Through the JAK-STAT, HIF-1, and PI3K-Akt signaling pathways, inflammatory factors drive the development of PCOS-IR in overweight PCOS patients (Yu et al., 2022)

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Interestingly, incretin-based antidiabetic therapies, including GLP-1 agonists and DPP-IV inhibitors, are known to exert pancreatic as well as extra pancreatic effects