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PLoS Biol 2018;16, e2004663, doi: Pasqualetti, P

Administration of synthetic IGF-1 increases the number of immature granule cells in the hippocampus and prevents traumatic brain injury-induced gastrointestinal dysfunction [237], suggesting its potential to overcome the inhibitory post-injury microenvironment

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The above studies all confirm that GPx4 is a key substance for targeted inhibition to alleviate ferroptosis and renal fibrosis