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While GIP indeed acts as an incretin in healthy individuals, researchers found an important limitation in patients with type 2 diabetes, GIP loses most of its insulinotropic efficacy (the pancreatic cells become GIP-resistant) ( [32] )
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Jaiswal P, Tripathi V, Nayak A, Kataria S, Lukashevich V, Das AK, et al
Worsening of diabetic retinopathy with rapid improvement in systemic glucose control - a review
Depending on the specific formulations, some prefer using them at different times of the day or alternating their use