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As is well known, CPT proteins (CPTI and CPTII) are involved in the transport of LCFAs from the cytosol into the mitochondrial matrix, where they are subsequently oxidized in the form of acyl-CoA esters (Houten et al., 2016)
Zhu et al., 2023)
To elucidate the effect of GCLC and glutathione loss on brain homeostasis, we biochemically and histochemically analyzed brain pathologies in neuronal GCLC-conditional knockout (GCLC floxed X CaMKII-Cre
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Jones B, Buenaventura T, Kanda N, et al
When glutathione levels are healthy, it helps neutralize this oxidative stress and calms the inflammatory response
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