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10.3322/caac.21660 42 TakahashiN.SaitoD.HasegawaS.YamasakiM.ImaiM

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Studies have shown that tamoxifen resistance is associated with IGFBP-1 accumulation and that the overexpression of IGFBP-1 promotes tamoxifen resistance in breast cancer cells by activating the ERK pathway, which can be reversed by knocking down IGFBP-1 (134)

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